This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for MLLT10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLLT10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLLT10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:21,281,583–21,282,796 | 242.4 kb | Distal (>10kb) Multiome HiCAR | 230 | |
| chr10:21,313,840–21,314,525 | 210.4 kb | Distal (>10kb) Multiome | 145 | |
| chr10:21,417,277–21,417,788 | 107.2 kb | Distal (>10kb) Multiome | 150 | |
| chr10:21,495,254–21,497,513 | 28.7 kb | Distal (>10kb) Multiome | 1097 | |
| chr10:21,508,081–21,511,137 | 14.0 kb | Distal (>10kb) Multiome | 373 | |
| chr10:21,515,560–21,517,745 | 8.5 kb | Proximal (<10kb) Multiome | 690 | |
| chr10:21,518,097–21,518,552 | 6.1 kb | Proximal (<10kb) | 246 | |
| chr10:21,520,150–21,520,286 | 4.4 kb | Proximal (<10kb) | 129 | |
| chr10:21,523,007–21,524,077 | 567 bp | At TSS | 224 | |
| chr10:21,524,213–21,526,810 | 1.4 kb | Proximal (<10kb) Multiome | 1100 | |
| chr10:21,527,043–21,527,629 | 2.8 kb | Proximal (<10kb) Multiome | 673 | |
| chr10:21,533,309–21,535,662 | 9.5 kb | Proximal (<10kb) Multiome | 1089 | |
| chr10:21,607,324–21,607,893 | 82.9 kb | Distal (>10kb) Multiome | 105 | |
| chr10:21,675,267–21,675,437 | 1.7 kb | Proximal (<10kb) | 100 | |
| chr10:21,727,364–21,728,215 | 203.2 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr10:21,751,037–21,752,796 | 227.0 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the MLLT10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.