Transcription factors with Perturb-seq knockdown data for MKRN2OS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MKRN2OS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MKRN2OS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:12,287,512–12,289,112 | 257.7 kb | Distal (>10kb) Multiome | 592 | |
| chr3:12,483,888–12,485,008 | 61.1 kb | Distal (>10kb) Multiome | 832 | |
| chr3:12,545,412–12,545,685 | at TSS | At TSS | 197 | |
| chr3:12,556,440–12,557,557 | 11.5 kb | Distal (>10kb) Multiome | 1025 | |
| chr3:12,663,393–12,664,764 | 118.7 kb | Distal (>10kb) Multiome | 941 | |
| chr3:12,768,768–12,769,541 | 223.5 kb | Distal (>10kb) Multiome | 69 | |
| chr3:12,796,430–12,797,162 | 251.3 kb | Distal (>10kb) Multiome | 467 | |
| chr3:12,809,737–12,810,783 | 264.9 kb | Distal (>10kb) Multiome | 598 | |
| chr3:12,833,218–12,834,303 | 288.0 kb | Distal (>10kb) Multiome | 191 | |
| chr3:12,841,044–12,841,991 | 296.1 kb | Distal (>10kb) Multiome | 956 |
Genomic view of the MKRN2OS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.