Transcription factors with Perturb-seq knockdown data for MIRLET7BHG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIRLET7BHG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIRLET7BHG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:45,978,612–45,979,356 | 93.3 kb | Distal (>10kb) Multiome | 567 | |
| chr22:46,013,459–46,014,306 | 58.5 kb | Distal (>10kb) Multiome | 814 | |
| chr22:46,035,443–46,036,717 | 36.4 kb | Distal (>10kb) Multiome | 735 | |
| chr22:46,061,373–46,062,193 | 10.5 kb | Distal (>10kb) Multiome | 257 | |
| chr22:46,070,177–46,072,638 | at TSS | At TSS | 557 | |
| chr22:46,116,470–46,116,929 | 44.4 kb | Distal (>10kb) Multiome | 471 | |
| chr22:46,149,521–46,151,433 | 77.9 kb | Distal (>10kb) Multiome | 562 | |
| chr22:46,249,918–46,250,866 | 178.1 kb | Distal (>10kb) Multiome | 831 | |
| chr22:46,262,531–46,263,383 | 190.7 kb | Distal (>10kb) Multiome | 169 | |
| chr22:46,267,542–46,268,277 | 195.6 kb | Distal (>10kb) Multiome | 725 | |
| chr22:46,296,072–46,297,498 | 224.5 kb | Distal (>10kb) Multiome | 810 | |
| chr22:46,335,274–46,336,005 | 263.3 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the MIRLET7BHG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.