Transcription factors with Perturb-seq knockdown data for MIR3681HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR3681HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR3681HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:11,743,889–11,745,399 | 262.9 kb | Distal (>10kb) Multiome | 874 | |
| chr2:11,745,980–11,747,523 | 260.5 kb | Distal (>10kb) Multiome | 809 | |
| chr2:11,829,052–11,830,741 | 176.9 kb | Distal (>10kb) Multiome | 941 | |
| chr2:11,863,504–11,864,327 | 143.2 kb | Distal (>10kb) Multiome | 541 | |
| chr2:12,003,225–12,003,472 | 3.7 kb | Proximal (<10kb) | 6 | |
| chr2:12,006,004–12,006,374 | 756 bp | At TSS | 286 | |
| chr2:12,006,830–12,007,217 | at TSS | At TSS | 128 | |
| chr2:12,082,609–12,083,841 | 76.2 kb | Distal (>10kb) Multiome | 391 | |
| chr2:12,313,746–12,314,792 | 307.2 kb | Distal (>10kb) Multiome | 173 |
Genomic view of the MIR3681HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.