Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIR34AHG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR34AHG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR34AHG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:9,128,169–9,129,971 | 53.0 kb | Distal (>10kb) Multiome | 749 | |
| chr1:9,181,345–9,181,788 | 606 bp | At TSS | 423 | |
| chr1:9,181,987–9,182,648 | at TSS | At TSS | 582 | |
| chr1:9,234,085–9,235,495 | 52.4 kb | Distal (>10kb) Multiome | 911 | |
| chr1:9,292,267–9,293,831 | 110.4 kb | Distal (>10kb) Multiome | 521 | |
| chr1:9,428,560–9,429,575 | 246.6 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the MIR34AHG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.