Transcription factors with Perturb-seq knockdown data for MIR181A1HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR181A1HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR181A1HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:198,701,348–198,702,544 | 235.5 kb | Distal (>10kb) Multiome | 113 | |
| chr1:198,930,016–198,930,578 | 6.9 kb | Proximal (<10kb) | 138 | |
| chr1:198,935,452–198,935,861 | 1.6 kb | Proximal (<10kb) | 431 | |
| chr1:198,937,202–198,937,721 | at TSS | At TSS | 316 | |
| chr1:198,939,300–198,939,851 | 1.8 kb | Proximal (<10kb) | 86 |
Genomic view of the MIR181A1HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.