This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for MIR100HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR100HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR100HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:121,655,309–121,656,263 | 444.7 kb | Distal (>10kb) Multiome HiCAR | 722 | |
| chr11:121,800,724–121,801,415 | 299.4 kb | Distal (>10kb) Multiome | 84 | |
| chr11:122,100,330–122,100,854 | 977 bp | At TSS | 86 | |
| chr11:122,101,726–122,102,200 | at TSS | At TSS | 191 | |
| chr11:122,105,535–122,105,697 | 3.7 kb | Proximal (<10kb) | 47 | |
| chr11:122,202,585–122,203,556 | 102.6 kb | Distal (>10kb) Multiome | 320 | |
| chr11:122,439,845–122,441,657 | 340.3 kb | Distal (>10kb) Multiome | 365 | |
| chr11:122,556,541–122,557,119 | 456.4 kb | Distal (>10kb) Multiome | 192 | |
| chr11:122,559,577–122,560,226 | 459.5 kb | Distal (>10kb) Multiome | 136 | |
| chr11:122,563,775–122,564,090 | 7.1 kb | Proximal (<10kb) | 20 | |
| chr11:122,655,417–122,657,184 | 555.3 kb | Distal (>10kb) Multiome | 620 |
Genomic view of the MIR100HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.