This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for MIEF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIEF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIEF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:17,971,984–17,973,164 | 288.0 kb | Distal (>10kb) Multiome | 716 | |
| chr17:18,035,659–18,036,594 | 224.6 kb | Distal (>10kb) Multiome | 186 | |
| chr17:18,038,656–18,040,279 | 221.3 kb | Distal (>10kb) Multiome | 839 | |
| chr17:18,153,365–18,154,352 | 106.7 kb | Distal (>10kb) Multiome | 244 | |
| chr17:18,157,790–18,158,725 | 102.4 kb | Distal (>10kb) Multiome | 292 | |
| chr17:18,182,585–18,185,065 | 77.1 kb | Distal (>10kb) Multiome | 1051 | |
| chr17:18,224,148–18,226,173 | 35.9 kb | Distal (>10kb) Multiome | 680 | |
| chr17:18,246,777–18,247,912 | 13.4 kb | Distal (>10kb) Multiome | 314 | |
| chr17:18,257,865–18,259,083 | 2.0 kb | Proximal (<10kb) Multiome | 684 | |
| chr17:18,260,145–18,261,582 | 15 bp | At TSS Multiome | 778 | |
| chr17:18,268,361–18,268,595 | 7.8 kb | Proximal (<10kb) | 55 | |
| chr17:18,314,513–18,315,715 | 54.5 kb | Distal (>10kb) Multiome | 865 | |
| chr17:18,363,090–18,363,830 | 102.9 kb | Distal (>10kb) Multiome | 760 |
Genomic view of the MIEF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.