Enables identical protein binding activity; mitochondrial large ribosomal subunit binding activity; and purine ribonucleotide binding activity. Involved in several processes, including mitochondrial large ribosomal subunit assembly; mitochondrion organization; and regulation of mitochondrion organization. Located in mitochondrial matrix and mitochondrial outer membrane. Implicated in optic atrophy. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIEF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIEF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIEF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:39,229,884–39,230,835 | 272.2 kb | Distal (>10kb) Multiome | 417 | |
| chr22:39,242,211–39,244,345 | 259.5 kb | Distal (>10kb) Multiome | 605 | |
| chr22:39,310,537–39,311,897 | 191.2 kb | Distal (>10kb) Multiome | 655 | |
| chr22:39,319,163–39,320,470 | 182.6 kb | Distal (>10kb) Multiome | 968 | |
| chr22:39,349,608–39,350,646 | 152.5 kb | Distal (>10kb) Multiome | 412 | |
| chr22:39,388,249–39,388,891 | 113.9 kb | Distal (>10kb) Multiome | 336 | |
| chr22:39,399,211–39,400,196 | 102.6 kb | Distal (>10kb) Multiome | 896 | |
| chr22:39,496,463–39,496,629 | 5.7 kb | Proximal (<10kb) | 242 | |
| chr22:39,501,766–39,502,757 | 54 bp | At TSS Multiome | 736 | |
| chr22:39,519,211–39,521,337 | 17.8 kb | Distal (>10kb) Multiome | 1150 | |
| chr22:39,528,868–39,529,848 | 27.0 kb | Distal (>10kb) Multiome | 829 | |
| chr22:39,532,183–39,533,171 | 30.5 kb | Distal (>10kb) Multiome | 799 | |
| chr22:39,534,113–39,535,455 | 32.6 kb | Distal (>10kb) Multiome | 621 | |
| chr22:39,598,010–39,598,521 | 96.0 kb | Distal (>10kb) Multiome | 163 | |
| chr22:39,661,773–39,663,221 | 160.2 kb | Distal (>10kb) Multiome | 260 | |
| chr22:39,663,880–39,665,145 | 162.3 kb | Distal (>10kb) Multiome | 208 |
Genomic view of the MIEF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.