Transcription factors with Perturb-seq knockdown data for MGC32805. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGC32805 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGC32805, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:122,310,677–122,313,387 | 166.7 kb | Distal (>10kb) Multiome | 423 | |
| chr5:122,471,290–122,471,857 | 7.0 kb | Proximal (<10kb) | 30 | |
| chr5:122,474,137–122,474,644 | 4.2 kb | Proximal (<10kb) | 41 | |
| chr5:122,477,454–122,477,791 | 1.1 kb | Proximal (<10kb) | 22 | |
| chr5:122,774,585–122,775,777 | 296.1 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the MGC32805 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.