The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MGAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:49,366,267–49,367,349 | 254.1 kb | Distal (>10kb) Multiome | 117 | |
| chr14:49,585,877–49,587,282 | 34.3 kb | Distal (>10kb) Multiome | 966 | |
| chr14:49,598,179–49,599,418 | 22.0 kb | Distal (>10kb) Multiome | 967 | |
| chr14:49,620,144–49,621,897 | 56 bp | At TSS Multiome | 930 | |
| chr14:49,633,485–49,635,896 | 13.6 kb | Distal (>10kb) Multiome | 1040 | |
| chr14:49,687,569–49,688,718 | 67.5 kb | Distal (>10kb) Multiome | 843 | |
| chr14:49,692,914–49,693,633 | 72.5 kb | Distal (>10kb) Multiome | 764 | |
| chr14:49,767,430–49,769,102 | 147.2 kb | Distal (>10kb) Multiome | 899 | |
| chr14:49,852,270–49,853,410 | 232.0 kb | Distal (>10kb) Multiome | 813 | |
| chr14:49,853,662–49,854,089 | 233.2 kb | Distal (>10kb) Multiome | 439 | |
| chr14:49,861,592–49,863,464 | 242.1 kb | Distal (>10kb) Multiome | 1038 | |
| chr14:49,867,745–49,868,682 | 247.4 kb | Distal (>10kb) Multiome | 699 | |
| chr14:49,892,363–49,894,019 | 272.2 kb | Distal (>10kb) Multiome | 981 |
Genomic view of the MGAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.