Enables sphingolipid transporter activity. Involved in lipid transport. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFSD2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFSD2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFSD2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:23,925,864–23,928,023 | 82.9 kb | Distal (>10kb) Multiome | 1102 | |
| chr2:23,939,310–23,941,043 | 69.6 kb | Distal (>10kb) Multiome | 856 | |
| chr2:24,009,633–24,010,873 | 151 bp | At TSS Multiome | 382 | |
| chr2:24,046,941–24,048,071 | 37.4 kb | Distal (>10kb) Multiome | 719 | |
| chr2:24,049,244–24,050,644 | 39.7 kb | Distal (>10kb) Multiome | 554 | |
| chr2:24,075,859–24,077,721 | 66.6 kb | Distal (>10kb) Multiome | 1100 | |
| chr2:24,083,513–24,085,355 | 74.4 kb | Distal (>10kb) Multiome | 1088 | |
| chr2:24,123,015–24,123,986 | 113.4 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the MFSD2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.