Enables dipeptide uniporter activity. Involved in dipeptide transmembrane transport from lysosomal lumen to cytosol. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFSD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFSD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFSD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:158,570,578–158,571,791 | 230.9 kb | Distal (>10kb) Multiome | 632 | |
| chr3:158,643,965–158,644,957 | 157.6 kb | Distal (>10kb) Multiome | 928 | |
| chr3:158,671,766–158,673,071 | 129.4 kb | Distal (>10kb) Multiome | 479 | |
| chr3:158,731,475–158,733,286 | 69.7 kb | Distal (>10kb) Multiome | 470 | |
| chr3:158,794,887–158,795,264 | 6.8 kb | Proximal (<10kb) | 136 | |
| chr3:158,801,057–158,802,803 | 69 bp | At TSS Multiome | 932 | |
| chr3:158,905,172–158,906,095 | 103.4 kb | Distal (>10kb) Multiome | 165 | |
| chr3:159,007,124–159,008,617 | 205.4 kb | Distal (>10kb) Multiome | 125 | |
| chr3:159,762,298–159,765,990 | 961.8 kb | Distal (>10kb) Multiome HiCAR | 826 | |
| chr3:159,839,632–159,840,400 | 1037.9 kb | Distal (>10kb) Multiome HiCAR | 356 |
Genomic view of the MFSD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.