This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for METTL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METTL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METTL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:21,268,822–21,270,154 | 241.7 kb | Distal (>10kb) Multiome | 1029 | |
| chr14:21,308,204–21,309,328 | 202.4 kb | Distal (>10kb) Multiome | 647 | |
| chr14:21,383,896–21,384,850 | 127.0 kb | Distal (>10kb) Multiome | 931 | |
| chr14:21,436,834–21,437,890 | 73.9 kb | Distal (>10kb) Multiome | 875 | |
| chr14:21,455,683–21,456,683 | 55.1 kb | Distal (>10kb) Multiome | 862 | |
| chr14:21,476,573–21,477,687 | 34.3 kb | Distal (>10kb) Multiome | 931 | |
| chr14:21,510,804–21,511,761 | 85 bp | At TSS Multiome | 972 | |
| chr14:21,525,630–21,527,355 | 15.1 kb | Distal (>10kb) Multiome | 627 | |
| chr14:21,534,439–21,535,312 | 23.5 kb | Distal (>10kb) Multiome | 146 | |
| chr14:21,536,256–21,537,359 | 25.6 kb | Distal (>10kb) Multiome | 181 | |
| chr14:21,557,417–21,557,905 | 46.3 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the METTL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.