Predicted to enable low-density lipoprotein particle receptor binding activity and protein folding chaperone. Involved in ossification and protein folding. Located in endoplasmic reticulum. Implicated in osteogenesis imperfecta type 20. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MESD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MESD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MESD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:80,694,769–80,696,059 | 294.6 kb | Distal (>10kb) Multiome | 455 | |
| chr15:80,778,964–80,780,209 | 210.6 kb | Distal (>10kb) Multiome | 528 | |
| chr15:80,780,345–80,780,949 | 209.1 kb | Distal (>10kb) Multiome | 676 | |
| chr15:80,970,143–80,970,321 | 8.8 kb | Proximal (<10kb) | 166 | |
| chr15:80,977,630–80,977,880 | 1.3 kb | Proximal (<10kb) | 204 | |
| chr15:80,989,298–80,990,315 | 43 bp | At TSS Multiome | 780 | |
| chr15:81,000,317–81,003,329 | 11.1 kb | Distal (>10kb) Multiome | 865 | |
| chr15:81,133,906–81,134,755 | 144.4 kb | Distal (>10kb) Multiome | 230 | |
| chr15:82,044,186–82,047,995 | 1056.3 kb | Distal (>10kb) Multiome HiCAR | 848 |
Genomic view of the MESD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.