Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MEGF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEGF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEGF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:65,981,906–65,982,587 | 271.4 kb | Distal (>10kb) Multiome | 319 | |
| chr15:66,252,061–66,253,967 | 1.6 kb | Proximal (<10kb) Multiome | 412 | |
| chr15:66,293,215–66,294,349 | 39.9 kb | Distal (>10kb) Multiome | 772 | |
| chr15:66,356,371–66,357,196 | 103.0 kb | Distal (>10kb) Multiome | 889 | |
| chr15:66,386,387–66,387,653 | 133.0 kb | Distal (>10kb) Multiome | 899 | |
| chr15:66,497,104–66,498,247 | 244.0 kb | Distal (>10kb) Multiome | 1044 | |
| chr15:66,504,543–66,505,655 | 251.3 kb | Distal (>10kb) Multiome | 940 |
Genomic view of the MEGF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.