Transcription factors with Perturb-seq knockdown data for MEF2C-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEF2C-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEF2C-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:88,666,812–88,667,946 | 8.1 kb | Proximal (<10kb) | 238 | |
| chr5:88,671,570–88,672,534 | 3.5 kb | Proximal (<10kb) | 221 | |
| chr5:88,672,665–88,673,110 | 2.9 kb | Proximal (<10kb) | 155 | |
| chr5:88,674,048–88,676,457 | at TSS | At TSS | 679 | |
| chr5:88,677,986–88,678,918 | 2.0 kb | Proximal (<10kb) | 165 | |
| chr5:88,680,113–88,681,161 | 4.1 kb | Proximal (<10kb) | 559 | |
| chr5:88,683,414–88,684,052 | 7.4 kb | Proximal (<10kb) | 254 | |
| chr5:88,684,266–88,685,701 | 8.3 kb | Proximal (<10kb) | 236 |
Genomic view of the MEF2C-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.