Predicted to enable transcription coregulator activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within limb development and negative regulation of fibroblast proliferation. Located in nucleus. Part of core mediator complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MED31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:5,468,372–5,469,379 | 1182.7 kb | Distal (>10kb) Multiome HiCAR | 890 | |
| chr17:6,443,586–6,444,814 | 207.4 kb | Distal (>10kb) Multiome | 802 | |
| chr17:6,495,892–6,496,452 | 155.4 kb | Distal (>10kb) Multiome | 104 | |
| chr17:6,556,250–6,556,832 | 95.0 kb | Distal (>10kb) Multiome | 166 | |
| chr17:6,640,233–6,641,593 | 10.7 kb | Distal (>10kb) Multiome | 878 | |
| chr17:6,650,954–6,652,333 | 38 bp | At TSS Multiome | 949 | |
| chr17:6,654,843–6,655,105 | 3.2 kb | Proximal (<10kb) | 156 | |
| chr17:6,713,294–6,714,088 | 62.0 kb | Distal (>10kb) Multiome | 535 | |
| chr17:6,831,647–6,832,107 | 180.2 kb | Distal (>10kb) Multiome | 202 | |
| chr17:7,012,245–7,012,890 | 360.9 kb | Distal (>10kb) Multiome HiCAR | 804 | |
| chr17:7,014,335–7,015,213 | 363.2 kb | Distal (>10kb) Multiome HiCAR | 842 |
Genomic view of the MED31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.