This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MED24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,753,811–39,754,996 | 300.0 kb | Distal (>10kb) Multiome | 1000 | |
| chr17:39,926,716–39,928,343 | 126.7 kb | Distal (>10kb) Multiome | 942 | |
| chr17:39,952,356–39,953,923 | 101.2 kb | Distal (>10kb) Multiome | 598 | |
| chr17:39,979,964–39,981,234 | 73.8 kb | Distal (>10kb) Multiome | 1148 | |
| chr17:40,054,311–40,054,810 | 136 bp | At TSS Multiome | 694 | |
| chr17:40,062,700–40,063,624 | 8.6 kb | Proximal (<10kb) Multiome | 609 | |
| chr17:40,075,390–40,075,997 | 21.3 kb | Distal (>10kb) Multiome | 556 | |
| chr17:40,098,950–40,099,858 | 44.9 kb | Distal (>10kb) Multiome | 997 | |
| chr17:40,100,155–40,101,301 | 46.4 kb | Distal (>10kb) Multiome | 954 | |
| chr17:40,111,702–40,112,164 | 57.5 kb | Distal (>10kb) Multiome | 678 | |
| chr17:40,113,185–40,113,691 | 59.0 kb | Distal (>10kb) Multiome | 864 | |
| chr17:40,121,452–40,123,602 | 67.5 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,139,909–40,141,108 | 86.0 kb | Distal (>10kb) Multiome | 1121 | |
| chr17:40,177,152–40,178,398 | 123.1 kb | Distal (>10kb) Multiome | 329 | |
| chr17:40,191,326–40,192,022 | 137.4 kb | Distal (>10kb) Multiome | 588 | |
| chr17:40,218,712–40,219,963 | 165.0 kb | Distal (>10kb) Multiome | 901 | |
| chr17:40,287,308–40,288,608 | 233.4 kb | Distal (>10kb) Multiome | 870 | |
| chr17:40,306,565–40,307,697 | 252.7 kb | Distal (>10kb) Multiome | 366 | |
| chr17:40,316,576–40,317,119 | 262.4 kb | Distal (>10kb) Multiome | 557 | |
| chr17:40,317,794–40,318,727 | 263.8 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,341,205–40,342,644 | 287.6 kb | Distal (>10kb) Multiome | 835 | |
| chr17:40,344,939–40,346,042 | 291.0 kb | Distal (>10kb) Multiome | 730 | |
| chr17:42,016,953–42,018,102 | 1963.1 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr17:42,019,726–42,020,334 | 1965.7 kb | Distal (>10kb) Multiome HiCAR | 791 |
Genomic view of the MED24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.