Involved in several processes, including TOR signaling; positive regulation of protein localization to lysosome; and response to insulin. Located in cytosol; lysosomal membrane; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MEAK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEAK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEAK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:84,268,108–84,268,844 | 236.2 kb | Distal (>10kb) Multiome | 42 | |
| chr16:84,367,919–84,368,944 | 136.2 kb | Distal (>10kb) Multiome | 287 | |
| chr16:84,504,051–84,505,316 | 109 bp | At TSS Multiome | 803 | |
| chr16:84,511,404–84,511,550 | 6.7 kb | Proximal (<10kb) | 326 | |
| chr16:84,617,446–84,619,117 | 113.5 kb | Distal (>10kb) Multiome | 844 | |
| chr16:84,648,019–84,649,061 | 143.9 kb | Distal (>10kb) Multiome | 797 | |
| chr16:84,699,238–84,700,817 | 195.3 kb | Distal (>10kb) Multiome | 876 |
Genomic view of the MEAK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.