This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for MEAF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEAF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEAF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:37,473,950–37,475,117 | 40.3 kb | Distal (>10kb) Multiome | 695 | |
| chr1:37,513,871–37,515,291 | 69 bp | At TSS Multiome | 884 | |
| chr1:37,553,845–37,554,497 | 39.5 kb | Distal (>10kb) Multiome | 748 | |
| chr1:37,556,626–37,557,247 | 42.2 kb | Distal (>10kb) Multiome | 284 | |
| chr1:37,595,631–37,596,377 | 81.2 kb | Distal (>10kb) Multiome | 754 | |
| chr1:37,634,598–37,635,064 | 120.0 kb | Distal (>10kb) Multiome | 192 | |
| chr1:37,663,328–37,663,865 | 148.8 kb | Distal (>10kb) Multiome | 44 | |
| chr1:37,690,078–37,690,919 | 175.8 kb | Distal (>10kb) Multiome | 679 | |
| chr1:37,691,459–37,692,843 | 177.6 kb | Distal (>10kb) Multiome | 781 | |
| chr1:37,752,766–37,753,277 | 238.3 kb | Distal (>10kb) Multiome | 223 | |
| chr1:37,793,768–37,794,528 | 279.4 kb | Distal (>10kb) Multiome | 567 | |
| chr1:37,807,583–37,809,057 | 293.5 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the MEAF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.