This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for MDGA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MDGA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MDGA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:37,647,989–37,649,458 | at TSS | At TSS | 333 | |
| chr6:37,650,027–37,650,487 | 1.4 kb | Proximal (<10kb) | 205 | |
| chr6:37,692,075–37,692,416 | 5.5 kb | Proximal (<10kb) | 374 | |
| chr6:37,697,011–37,698,118 | at TSS | At TSS | 456 | |
| chr6:37,698,387–37,698,880 | 504 bp | At TSS | 379 | |
| chr6:37,698,953–37,699,233 | 1.1 kb | Proximal (<10kb) | 337 | |
| chr6:37,700,339–37,700,619 | 2.5 kb | Proximal (<10kb) | 46 | |
| chr6:37,705,006–37,706,173 | 7.1 kb | Proximal (<10kb) | 470 |
Genomic view of the MDGA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.