Enables RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Is active in cytoplasm. Implicated in immunodeficiency 118. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MCTS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCTS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCTS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:120,309,330–120,309,857 | 294.4 kb | Distal (>10kb) Multiome | 479 | |
| chrX:120,468,789–120,469,502 | 134.8 kb | Distal (>10kb) Multiome | 589 | |
| chrX:120,485,807–120,486,482 | 118.0 kb | Distal (>10kb) Multiome | 698 | |
| chrX:120,560,301–120,561,794 | 43.0 kb | Distal (>10kb) Multiome HiCAR | 727 | |
| chrX:120,603,687–120,604,407 | 94 bp | At TSS Multiome | 581 | |
| chrX:120,629,690–120,630,593 | 26.0 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the MCTS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.