Predicted to enable ATP binding activity and DNA binding activity. Predicted to be involved in double-strand break repair via break-induced replication. Predicted to act upstream of or within meiosis I cell cycle process; oogenesis; and spermatogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MCMDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCMDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCMDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:66,612,352–66,614,219 | 257.4 kb | Distal (>10kb) Multiome | 862 | |
| chr8:66,666,261–66,667,884 | 203.4 kb | Distal (>10kb) Multiome | 889 | |
| chr8:66,712,294–66,713,281 | 158.0 kb | Distal (>10kb) Multiome | 648 | |
| chr8:66,774,026–66,775,860 | 95.6 kb | Distal (>10kb) Multiome | 957 | |
| chr8:66,870,495–66,871,236 | 50 bp | At TSS Multiome | 352 | |
| chr8:66,924,535–66,926,136 | 54.8 kb | Distal (>10kb) Multiome | 998 | |
| chr8:66,961,090–66,963,532 | 90.6 kb | Distal (>10kb) Multiome | 438 | |
| chr8:67,028,419–67,029,071 | 157.9 kb | Distal (>10kb) Multiome | 488 | |
| chr8:67,061,734–67,062,754 | 191.5 kb | Distal (>10kb) Multiome | 733 | |
| chr8:67,063,914–67,065,235 | 193.6 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the MCMDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.