Enables identical protein binding activity and protein kinase inhibitor activity. Involved in several processes, including positive regulation of JNK cascade; regulation of cell division; and regulation of gene expression. Located in cytosol; nucleolus; and nucleoplasm. Part of ATAC complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MBIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MBIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MBIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:36,161,684–36,162,507 | 158.5 kb | Distal (>10kb) Multiome | 96 | |
| chr14:36,244,790–36,245,848 | 75.3 kb | Distal (>10kb) Multiome | 128 | |
| chr14:36,320,098–36,321,234 | 10 bp | At TSS Multiome | 935 | |
| chr14:36,512,403–36,513,922 | 192.5 kb | Distal (>10kb) Multiome | 230 | |
| chr14:36,517,184–36,521,366 | 199.2 kb | Distal (>10kb) Multiome | 575 | |
| chr14:36,524,671–36,525,867 | 205.0 kb | Distal (>10kb) Multiome | 355 | |
| chr14:36,580,686–36,581,853 | 260.5 kb | Distal (>10kb) Multiome | 263 | |
| chr14:36,582,029–36,583,382 | 262.0 kb | Distal (>10kb) Multiome | 304 |
Genomic view of the MBIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.