This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MATN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MATN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MATN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:97,643,510–97,645,718 | 225.0 kb | Distal (>10kb) Multiome | 951 | |
| chr8:97,761,283–97,761,890 | 107.5 kb | Distal (>10kb) Multiome | 88 | |
| chr8:97,774,820–97,776,789 | 93.5 kb | Distal (>10kb) Multiome | 1013 | |
| chr8:97,778,238–97,780,015 | 90.5 kb | Distal (>10kb) Multiome | 400 | |
| chr8:97,781,999–97,784,345 | 85.5 kb | Distal (>10kb) Multiome | 298 | |
| chr8:97,867,534–97,868,376 | 776 bp | At TSS | 79 | |
| chr8:97,868,488–97,870,075 | 282 bp | At TSS Multiome | 498 | |
| chr8:97,932,331–97,934,476 | 64.7 kb | Distal (>10kb) Multiome | 228 | |
| chr8:98,011,075–98,011,541 | 142.0 kb | Distal (>10kb) Multiome | 178 | |
| chr8:98,045,232–98,046,414 | 176.5 kb | Distal (>10kb) Multiome HiCAR | 829 | |
| chr8:98,064,246–98,065,195 | 195.6 kb | Distal (>10kb) Multiome HiCAR | 385 | |
| chr8:98,116,581–98,117,836 | 248.0 kb | Distal (>10kb) Multiome | 829 |
Genomic view of the MATN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.