Predicted to enable carboxypeptidase activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MATCAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MATCAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MATCAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:36,112,818–36,113,397 | 254.1 kb | Distal (>10kb) Multiome | 87 | |
| chr7:36,152,317–36,154,017 | 214.3 kb | Distal (>10kb) Multiome | 781 | |
| chr7:36,258,280–36,258,762 | 108.6 kb | Distal (>10kb) Multiome | 236 | |
| chr7:36,278,017–36,278,924 | 88.9 kb | Distal (>10kb) Multiome | 133 | |
| chr7:36,317,138–36,318,414 | 49.7 kb | Distal (>10kb) Multiome | 28 | |
| chr7:36,359,771–36,360,034 | 7.2 kb | Proximal (<10kb) | 12 | |
| chr7:36,360,310–36,360,597 | 6.6 kb | Proximal (<10kb) | 142 | |
| chr7:36,366,649–36,367,847 | 27 bp | At TSS Multiome | 792 | |
| chr7:36,388,932–36,390,769 | 22.6 kb | Distal (>10kb) Multiome | 1029 |
Genomic view of the MATCAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.