MAPRE3

microtubule associated protein RP/EB family member 3 | EB3, RP3

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

Biological processes 33 terms

behavioral response to cocaine (GO:0048148)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic microtubule (GO:0005881)cytoskeleton (GO:0005856)identical protein binding (GO:0042802)intracellular protein localization (GO:0008104)microtubule (GO:0005874)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule cytoskeleton (GO:0015630)microtubule cytoskeleton (GO:0015630)microtubule organizing center (GO:0005815)microtubule plus-end (GO:0035371)microtubule plus-end (GO:0035371)microtubule plus-end binding (GO:0051010)microtubule plus-end binding (GO:0051010)midbody (GO:0030496)midbody (GO:0030496)mitotic spindle astral microtubule end (GO:1905721)neuron to neuron synapse (GO:0098984)perinuclear region of cytoplasm (GO:0048471)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of dendritic spine morphogenesis (GO:0061003)protein binding (GO:0005515)protein localization to microtubule (GO:0035372)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase binding (GO:0120283)regulation of microtubule polymerization (GO:0031113)regulation of microtubule polymerization or depolymerization (GO:0031110)spindle assembly (GO:0051225)spindle midzone (GO:0051233)

Expression (TPM)

TFs regulating MAPRE3 0 TFs

Transcription factors with Perturb-seq knockdown data for MAPRE3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPRE3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAPRE3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPRE3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:26,692,280–26,693,600	277.9 kb	Distal (>10kb) Multiome	275
chr2:26,749,944–26,750,505	220.5 kb	Distal (>10kb) Multiome	322
chr2:26,764,126–26,764,575	206.4 kb	Distal (>10kb) Multiome	781
chr2:26,785,402–26,786,601	184.7 kb	Distal (>10kb) Multiome	996
chr2:26,846,388–26,846,855	124.1 kb	Distal (>10kb) Multiome	343
chr2:26,847,436–26,849,494	122.7 kb	Distal (>10kb) Multiome	447
chr2:26,961,589–26,962,066	8.7 kb	Proximal (<10kb) Multiome	502
chr2:26,970,294–26,971,331	88 bp	At TSS Multiome	572
chr2:27,032,577–27,033,271	62.3 kb	Distal (>10kb) Multiome	799
chr2:27,049,564–27,052,299	80.9 kb	Distal (>10kb) Multiome	1295
chr2:27,071,223–27,072,896	101.2 kb	Distal (>10kb) Multiome	864
chr2:27,081,006–27,081,641	110.7 kb	Distal (>10kb) Multiome	758
chr2:27,085,591–27,087,452	116.0 kb	Distal (>10kb) Multiome	970
chr2:27,123,498–27,124,089	153.2 kb	Distal (>10kb) Multiome	553
chr2:27,133,917–27,135,216	164.0 kb	Distal (>10kb) Multiome	815
chr2:27,211,255–27,212,840	241.4 kb	Distal (>10kb) Multiome	978
chr2:27,217,045–27,218,005	246.8 kb	Distal (>10kb) Multiome	771
chr2:27,250,040–27,250,883	279.8 kb	Distal (>10kb) Multiome	559
chr2:27,262,260–27,263,337	292.2 kb	Distal (>10kb) Multiome	376
chr2:27,264,406–27,265,326	294.5 kb	Distal (>10kb) Multiome	696

Genome Browser

Genomic view of the MAPRE3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.