This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for MAPK8IP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK8IP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK8IP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:45,655,292–45,655,791 | 230.2 kb | Distal (>10kb) Multiome | 271 | |
| chr11:45,664,518–45,666,069 | 220.0 kb | Distal (>10kb) Multiome | 223 | |
| chr11:45,771,302–45,772,261 | 113.6 kb | Distal (>10kb) Multiome | 510 | |
| chr11:45,803,866–45,805,789 | 81.6 kb | Distal (>10kb) Multiome | 806 | |
| chr11:45,847,011–45,848,213 | 38.3 kb | Distal (>10kb) Multiome | 845 | |
| chr11:45,885,234–45,886,606 | 19 bp | At TSS Multiome | 501 | |
| chr11:45,899,383–45,900,756 | 14.3 kb | Distal (>10kb) Multiome | 534 | |
| chr11:45,917,590–45,918,966 | 32.4 kb | Distal (>10kb) Multiome | 781 | |
| chr11:45,921,513–45,923,586 | 36.8 kb | Distal (>10kb) Multiome | 624 | |
| chr11:46,120,416–46,122,472 | 235.8 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the MAPK8IP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.