Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAPK12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:49,999,173–50,000,437 | 262.1 kb | Distal (>10kb) Multiome | 237 | |
| chr22:50,030,288–50,030,739 | 231.3 kb | Distal (>10kb) Multiome | 433 | |
| chr22:50,184,288–50,186,776 | 75.9 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 60.7 kb | Distal (>10kb) Multiome | 612 | |
| chr22:50,244,340–50,245,635 | 16.6 kb | Distal (>10kb) Multiome | 868 | |
| chr22:50,250,480–50,251,917 | 10.4 kb | Distal (>10kb) Multiome | 683 | |
| chr22:50,252,224–50,252,418 | 9.3 kb | Proximal (<10kb) | 229 | |
| chr22:50,261,070–50,261,932 | 68 bp | At TSS Multiome | 512 | |
| chr22:50,267,469–50,268,208 | 6.0 kb | Proximal (<10kb) Multiome | 196 | |
| chr22:50,270,036–50,270,468 | 8.3 kb | Proximal (<10kb) | 177 | |
| chr22:50,270,825–50,271,023 | 9.1 kb | Proximal (<10kb) | 604 | |
| chr22:50,271,717–50,272,193 | 10.2 kb | Distal (>10kb) Multiome | 331 | |
| chr22:50,299,702–50,300,750 | 38.7 kb | Distal (>10kb) Multiome | 250 | |
| chr22:50,307,140–50,307,760 | 45.8 kb | Distal (>10kb) Multiome | 392 | |
| chr22:50,326,615–50,327,631 | 65.4 kb | Distal (>10kb) Multiome | 754 | |
| chr22:50,342,153–50,342,608 | 80.8 kb | Distal (>10kb) Multiome | 553 | |
| chr22:50,342,772–50,343,603 | 81.5 kb | Distal (>10kb) Multiome | 573 | |
| chr22:50,474,348–50,475,571 | 213.4 kb | Distal (>10kb) Multiome | 487 | |
| chr22:50,481,062–50,482,150 | 219.8 kb | Distal (>10kb) Multiome | 387 | |
| chr22:50,506,343–50,508,710 | 246.3 kb | Distal (>10kb) Multiome | 856 | |
| chr22:50,524,965–50,527,480 | 264.1 kb | Distal (>10kb) Multiome | 1031 |
Genomic view of the MAPK12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.