Predicted to enable kinesin binding activity and microtubule binding activity. Predicted to be involved in axon development and microtubule cytoskeleton organization. Predicted to be located in axon; microtubule cytoskeleton; and midbody. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MAP7D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP7D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP7D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:19,887,617–19,888,819 | 229.1 kb | Distal (>10kb) Multiome | 556 | |
| chrX:19,990,480–19,991,602 | 125.8 kb | Distal (>10kb) Multiome | 509 | |
| chrX:20,116,052–20,116,436 | 470 bp | At TSS | 205 | |
| chrX:20,116,546–20,117,083 | at TSS | At TSS | 230 | |
| chrX:20,141,297–20,142,342 | 25.0 kb | Distal (>10kb) Multiome | 557 | |
| chrX:20,266,335–20,268,799 | 150.2 kb | Distal (>10kb) Multiome | 680 |
Genomic view of the MAP7D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.