Enables DNA binding activity and cytoskeletal protein binding activity. Involved in metaphase chromosome alignment; microtubule cytoskeleton organization; and neuron projection morphogenesis. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAP1S. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP1S upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP1S, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,419,503–17,420,821 | 299.6 kb | Distal (>10kb) Multiome | 869 | |
| chr19:17,424,865–17,425,411 | 294.4 kb | Distal (>10kb) Multiome | 328 | |
| chr19:17,448,174–17,448,841 | 270.8 kb | Distal (>10kb) Multiome | 392 | |
| chr19:17,468,858–17,470,905 | 249.4 kb | Distal (>10kb) Multiome | 743 | |
| chr19:17,488,739–17,489,689 | 230.3 kb | Distal (>10kb) Multiome | 381 | |
| chr19:17,511,113–17,512,592 | 208.0 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:17,538,878–17,540,353 | 179.7 kb | Distal (>10kb) Multiome | 725 | |
| chr19:17,555,194–17,556,523 | 163.9 kb | Distal (>10kb) Multiome | 713 | |
| chr19:17,576,463–17,577,455 | 142.5 kb | Distal (>10kb) Multiome | 236 | |
| chr19:17,579,580–17,580,242 | 139.5 kb | Distal (>10kb) Multiome | 281 | |
| chr19:17,605,468–17,607,009 | 113.3 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:17,686,280–17,688,656 | 32.7 kb | Distal (>10kb) Multiome | 586 | |
| chr19:17,719,144–17,719,957 | 24 bp | At TSS Multiome | 585 | |
| chr19:17,747,227–17,748,170 | 28.2 kb | Distal (>10kb) Multiome | 503 | |
| chr19:17,762,487–17,762,985 | 43.2 kb | Distal (>10kb) Multiome | 199 | |
| chr19:17,778,112–17,778,869 | 58.9 kb | Distal (>10kb) Multiome | 311 | |
| chr19:17,794,880–17,795,385 | 75.6 kb | Distal (>10kb) Multiome | 465 | |
| chr19:17,829,926–17,831,824 | 111.5 kb | Distal (>10kb) Multiome | 466 | |
| chr19:17,841,205–17,843,221 | 122.6 kb | Distal (>10kb) Multiome | 545 | |
| chr19:17,847,546–17,848,187 | 128.2 kb | Distal (>10kb) Multiome | 437 | |
| chr19:17,859,472–17,860,202 | 140.3 kb | Distal (>10kb) Multiome | 822 | |
| chr19:17,873,769–17,874,763 | 154.8 kb | Distal (>10kb) Multiome | 303 | |
| chr19:17,931,700–17,932,248 | 212.4 kb | Distal (>10kb) Multiome | 136 | |
| chr19:17,932,373–17,933,607 | 213.3 kb | Distal (>10kb) Multiome | 924 | |
| chr19:17,942,639–17,943,673 | 223.8 kb | Distal (>10kb) Multiome | 302 | |
| chr19:17,947,203–17,950,613 | 228.6 kb | Distal (>10kb) Multiome | 639 | |
| chr19:17,951,201–17,952,652 | 232.8 kb | Distal (>10kb) Multiome | 237 | |
| chr19:17,966,756–17,967,353 | 247.6 kb | Distal (>10kb) Multiome | 127 | |
| chr19:18,000,754–18,001,614 | 281.7 kb | Distal (>10kb) Multiome | 788 | |
| chr19:18,007,024–18,008,451 | 288.6 kb | Distal (>10kb) Multiome | 681 |
Genomic view of the MAP1S locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.