Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MANBAL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MANBAL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MANBAL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:37,095,487–37,096,500 | 193.8 kb | Distal (>10kb) Multiome | 1181 | |
| chr20:37,178,598–37,179,693 | 110.6 kb | Distal (>10kb) Multiome | 977 | |
| chr20:37,289,329–37,289,991 | 15 bp | At TSS Multiome | 1018 | |
| chr20:37,295,615–37,295,890 | 6.0 kb | Proximal (<10kb) | 92 | |
| chr20:37,319,185–37,319,833 | 29.8 kb | Distal (>10kb) Multiome | 87 | |
| chr20:37,345,682–37,346,478 | 56.4 kb | Distal (>10kb) Multiome | 557 | |
| chr20:37,396,207–37,397,008 | 106.9 kb | Distal (>10kb) Multiome HiCAR | 227 | |
| chr20:37,520,318–37,521,734 | 231.6 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr20:37,527,439–37,528,617 | 238.3 kb | Distal (>10kb) Multiome HiCAR | 899 | |
| chr20:37,564,323–37,564,876 | 274.9 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the MANBAL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.