Predicted to enable alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process. Located in nucleoplasm. Implicated in congenital disorder of deglycosylation 2. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAN2C1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN2C1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN2C1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:75,140,133–75,140,707 | 228.2 kb | Distal (>10kb) Multiome | 536 | |
| chr15:75,178,233–75,178,833 | 190.1 kb | Distal (>10kb) Multiome | 386 | |
| chr15:75,200,527–75,203,502 | 166.6 kb | Distal (>10kb) Multiome | 928 | |
| chr15:75,335,855–75,336,339 | 32.6 kb | Distal (>10kb) Multiome | 665 | |
| chr15:75,346,877–75,348,733 | 21.2 kb | Distal (>10kb) Multiome | 738 | |
| chr15:75,367,625–75,369,002 | 467 bp | At TSS Multiome | 1121 | |
| chr15:75,450,273–75,456,388 | 87.3 kb | Distal (>10kb) Multiome | 1174 | |
| chr15:75,579,138–75,580,015 | 210.9 kb | Distal (>10kb) Multiome | 683 | |
| chr15:75,624,816–75,626,356 | 257.1 kb | Distal (>10kb) Multiome HiCAR | 987 | |
| chr15:75,639,562–75,640,798 | 271.7 kb | Distal (>10kb) Multiome HiCAR | 999 | |
| chr15:75,647,017–75,648,674 | 279.2 kb | Distal (>10kb) Multiome HiCAR | 795 |
Genomic view of the MAN2C1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.