Predicted to enable protein histidine phosphatase activity. Predicted to be involved in peptidyl-histidine dephosphorylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MAMDC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAMDC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAMDC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,840,460–136,841,401 | 9.5 kb | Proximal (<10kb) | 399 | |
| chr9:136,842,325–136,842,872 | 8.1 kb | Proximal (<10kb) | 492 | |
| chr9:136,843,849–136,845,157 | 5.8 kb | Proximal (<10kb) | 100 | |
| chr9:136,846,187–136,850,214 | 728 bp | At TSS | 1074 |
Genomic view of the MAMDC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.