Transcription factors with Perturb-seq knockdown data for MAGIX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAGIX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAGIX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:49,155,279–49,155,538 | 8.4 kb | Proximal (<10kb) | 181 | |
| chrX:49,155,633–49,156,658 | 7.3 kb | Proximal (<10kb) | 524 | |
| chrX:49,163,555–49,164,377 | at TSS | At TSS | 485 | |
| chrX:49,166,140–49,166,713 | 2.2 kb | Proximal (<10kb) | 416 |
Genomic view of the MAGIX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.