Transcription factors with Perturb-seq knockdown data for MAD2L1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAD2L1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAD2L1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:119,627,005–119,629,431 | 438.0 kb | Distal (>10kb) Multiome HiCAR | 731 | |
| chr4:120,066,153–120,067,563 | 40 bp | At TSS Multiome | 906 | |
| chr4:120,067,811–120,068,290 | 857 bp | At TSS | 136 | |
| chr4:120,071,116–120,071,695 | 4.2 kb | Proximal (<10kb) | 75 | |
| chr4:120,921,437–120,923,278 | 855.9 kb | Distal (>10kb) Multiome HiCAR | 557 | |
| chr4:121,070,302–121,071,684 | 1004.4 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr4:121,252,291–121,253,003 | 1185.6 kb | Distal (>10kb) Multiome HiCAR | 155 |
Genomic view of the MAD2L1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.