This gene, MACIR (previously known as C5orf30), has been associated with rheumatoid arthritis, functioning as a negative regulator of tissue damage and modulating the activity of synovial fibroblasts and macrophages. The encoded protein is highly conserved in vertebrate genomes but has no significant similarity to any other human protein. [provided by RefSeq, Dec 2019]
Transcription factors with Perturb-seq knockdown data for MACIR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MACIR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MACIR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:103,119,392–103,121,169 | 138.6 kb | Distal (>10kb) Multiome | 1050 | |
| chr5:103,223,049–103,225,117 | 34.0 kb | Distal (>10kb) Multiome | 339 | |
| chr5:103,243,524–103,244,857 | 14.8 kb | Distal (>10kb) Multiome | 129 | |
| chr5:103,256,277–103,256,450 | 2.3 kb | Proximal (<10kb) | 38 | |
| chr5:103,258,219–103,260,199 | 91 bp | At TSS Multiome | 874 |
Genomic view of the MACIR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.