This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5' UTR may play a role in a variety of psychiatric disorders. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for MAB21L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAB21L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAB21L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:35,470,608–35,471,528 | 7.2 kb | Proximal (<10kb) | 256 | |
| chr13:35,474,716–35,474,841 | 3.9 kb | Proximal (<10kb) | 35 | |
| chr13:35,475,095–35,476,494 | 2.3 kb | Proximal (<10kb) | 287 | |
| chr13:35,476,554–35,476,838 | 1.9 kb | Proximal (<10kb) | 150 | |
| chr13:35,478,275–35,479,368 | at TSS | At TSS | 229 |
Genomic view of the MAB21L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.