This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
Transcription factors with Perturb-seq knockdown data for LYST. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYST upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYST, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:235,642,093–235,643,505 | 223.7 kb | Distal (>10kb) Multiome | 410 | |
| chr1:235,648,967–235,650,841 | 216.7 kb | Distal (>10kb) Multiome | 689 | |
| chr1:235,866,120–235,867,793 | 118 bp | At TSS Multiome | 845 | |
| chr1:235,971,561–235,972,553 | 105.1 kb | Distal (>10kb) Multiome HiCAR | 595 | |
| chr1:236,063,919–236,065,936 | 198.2 kb | Distal (>10kb) Multiome | 930 | |
| chr1:236,140,574–236,141,829 | 274.0 kb | Distal (>10kb) Multiome | 321 | |
| chr1:236,141,986–236,143,622 | 275.6 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the LYST locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.