LY6G5B

lymphocyte antigen 6 family member G5B | G5b, C6orf19

LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]

Biological processes 6 terms

external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)extracellular region (GO:0005576)identical protein binding (GO:0042802)protein-containing complex (GO:0032991)

Expression (TPM)

TFs regulating LY6G5B 0 TFs

Transcription factors with Perturb-seq knockdown data for LY6G5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LY6G5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LY6G5B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LY6G5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:31,399,631–31,400,231	270.6 kb	Distal (>10kb) Multiome	678
chr6:31,403,046–31,404,269	266.9 kb	Distal (>10kb) Multiome	796
chr6:31,441,682–31,442,105	228.6 kb	Distal (>10kb) Multiome	316
chr6:31,462,703–31,463,323	207.3 kb	Distal (>10kb) Multiome	352
chr6:31,497,638–31,498,615	172.3 kb	Distal (>10kb) Multiome	613
chr6:31,541,205–31,542,816	128.2 kb	Distal (>10kb) Multiome	1073
chr6:31,546,485–31,547,136	123.6 kb	Distal (>10kb) Multiome	589
chr6:31,547,301–31,547,742	122.7 kb	Distal (>10kb) Multiome	762
chr6:31,580,713–31,581,330	89.3 kb	Distal (>10kb) Multiome	745
chr6:31,619,744–31,621,435	49.8 kb	Distal (>10kb) Multiome	1127
chr6:31,651,682–31,653,297	17.7 kb	Distal (>10kb) Multiome	1113
chr6:31,660,325–31,660,941	9.6 kb	Proximal (<10kb) Multiome	892
chr6:31,664,725–31,666,373	5.5 kb	Proximal (<10kb) Multiome	1039
chr6:31,682,887–31,683,880	13.0 kb	Distal (>10kb) Multiome	248
chr6:31,702,816–31,703,520	32.9 kb	Distal (>10kb) Multiome	875
chr6:31,728,852–31,730,814	59.3 kb	Distal (>10kb) Multiome	979
chr6:31,739,236–31,740,741	69.6 kb	Distal (>10kb) Multiome	1043
chr6:31,766,045–31,766,778	96.0 kb	Distal (>10kb) Multiome	351
chr6:31,795,097–31,796,366	125.6 kb	Distal (>10kb) Multiome	979
chr6:31,806,162–31,807,183	136.5 kb	Distal (>10kb) Multiome	947
chr6:31,814,125–31,815,936	144.2 kb	Distal (>10kb) Multiome	822
chr6:31,821,306–31,822,544	151.6 kb	Distal (>10kb) Multiome	714
chr6:31,826,770–31,828,135	157.1 kb	Distal (>10kb) Multiome	1000
chr6:31,834,277–31,835,371	164.3 kb	Distal (>10kb) Multiome	1085
chr6:31,862,148–31,864,173	193.6 kb	Distal (>10kb) Multiome	1118
chr6:31,896,965–31,898,037	227.2 kb	Distal (>10kb) Multiome	654
chr6:31,901,114–31,902,643	231.9 kb	Distal (>10kb) Multiome	826
chr6:31,958,527–31,959,598	288.7 kb	Distal (>10kb) Multiome	953

Genome Browser

Genomic view of the LY6G5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.