This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for LXN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LXN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LXN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:158,570,578–158,571,791 | 101.5 kb | Distal (>10kb) Multiome | 632 | |
| chr3:158,643,965–158,644,957 | 28.1 kb | Distal (>10kb) Multiome | 928 | |
| chr3:158,671,766–158,673,071 | 14 bp | At TSS Multiome | 479 | |
| chr3:158,731,475–158,733,286 | 59.7 kb | Distal (>10kb) Multiome | 470 | |
| chr3:158,801,057–158,802,803 | 129.4 kb | Distal (>10kb) Multiome | 932 | |
| chr3:158,905,172–158,906,095 | 232.8 kb | Distal (>10kb) Multiome | 165 |
Genomic view of the LXN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.