The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for LTBP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LTBP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LTBP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,261,186–65,262,526 | 278.8 kb | Distal (>10kb) Multiome | 777 | |
| chr11:65,314,302–65,316,053 | 225.9 kb | Distal (>10kb) Multiome | 803 | |
| chr11:65,333,360–65,334,372 | 206.8 kb | Distal (>10kb) Multiome | 654 | |
| chr11:65,354,023–65,355,987 | 186.0 kb | Distal (>10kb) Multiome | 677 | |
| chr11:65,386,320–65,387,097 | 154.0 kb | Distal (>10kb) Multiome | 757 | |
| chr11:65,416,383–65,417,015 | 124.2 kb | Distal (>10kb) Multiome | 664 | |
| chr11:65,417,855–65,419,687 | 121.6 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:65,421,858–65,423,533 | 118.3 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 85.5 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 63.1 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 52.9 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 43.1 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:65,524,475–65,525,724 | 15.6 kb | Distal (>10kb) Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 911 bp | At TSS Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 6.0 kb | Proximal (<10kb) Multiome | 529 | |
| chr11:65,550,948–65,551,290 | 4.2 kb | Proximal (<10kb) | 305 | |
| chr11:65,552,163–65,552,337 | 5.4 kb | Proximal (<10kb) | 393 | |
| chr11:65,553,318–65,554,003 | 13.0 kb | Distal (>10kb) Multiome | 195 | |
| chr11:65,569,718–65,570,745 | 29.6 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr11:65,571,973–65,573,008 | 31.8 kb | Distal (>10kb) Multiome HiCAR | 420 | |
| chr11:65,573,788–65,575,269 | 33.7 kb | Distal (>10kb) Multiome HiCAR | 742 | |
| chr11:65,591,808–65,592,698 | 51.5 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 66.5 kb | Distal (>10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 73.5 kb | Distal (>10kb) Multiome | 702 | |
| chr11:65,614,954–65,616,793 | 74.9 kb | Distal (>10kb) Multiome | 830 | |
| chr11:65,637,768–65,638,920 | 97.4 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,641,918–65,642,633 | 101.5 kb | Distal (>10kb) Multiome | 155 | |
| chr11:65,646,814–65,647,818 | 106.6 kb | Distal (>10kb) Multiome | 270 | |
| chr11:65,652,106–65,653,317 | 112.1 kb | Distal (>10kb) Multiome | 901 | |
| chr11:65,662,517–65,663,930 | 122.4 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,711,437–65,712,942 | 171.6 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 180.0 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 239.4 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 247.7 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 277.6 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 293.1 kb | Distal (>10kb) Multiome | 396 |
Genomic view of the LTBP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.