This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for LRRK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:100,703,026–100,703,737 | 216.0 kb | Distal (>10kb) Multiome | 232 | |
| chr15:100,759,705–100,760,315 | 159.4 kb | Distal (>10kb) Multiome | 302 | |
| chr15:100,878,673–100,880,993 | 39.7 kb | Distal (>10kb) Multiome | 455 | |
| chr15:100,917,841–100,918,691 | 1.2 kb | Proximal (<10kb) Multiome | 405 | |
| chr15:100,918,843–100,920,172 | 164 bp | At TSS Multiome | 364 | |
| chr15:101,008,268–101,008,757 | 89.3 kb | Distal (>10kb) Multiome HiCAR | 571 | |
| chr15:101,068,707–101,069,646 | 149.9 kb | Distal (>10kb) Multiome | 435 | |
| chr15:101,077,927–101,078,550 | 158.8 kb | Distal (>10kb) Multiome | 35 | |
| chr15:101,088,678–101,089,262 | 169.7 kb | Distal (>10kb) Multiome | 541 | |
| chr15:101,201,405–101,201,942 | 282.3 kb | Distal (>10kb) Multiome | 276 | |
| chr15:101,250,886–101,252,530 | 332.7 kb | Distal (>10kb) Multiome HiCAR | 729 |
Genomic view of the LRRK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.