Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:59,630,298–59,630,972 | 289.1 kb | Distal (>10kb) Multiome HiCAR | 239 | |
| chr14:59,870,241–59,871,387 | 48.9 kb | Distal (>10kb) Multiome | 433 | |
| chr14:59,918,862–59,919,022 | 689 bp | At TSS | 57 | |
| chr14:59,919,228–59,920,620 | 309 bp | At TSS Multiome | 615 | |
| chr14:60,091,167–60,092,522 | 172.3 kb | Distal (>10kb) Multiome | 1039 | |
| chr14:60,164,676–60,165,904 | 245.6 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the LRRC9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.