Transcription factors with Perturb-seq knockdown data for LRRC8C-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC8C-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC8C-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:89,523,795–89,525,737 | 108.1 kb | Distal (>10kb) Multiome | 1043 | |
| chr1:89,632,202–89,634,220 | 92 bp | At TSS Multiome | 718 | |
| chr1:89,762,558–89,763,791 | 130.2 kb | Distal (>10kb) Multiome | 638 | |
| chr1:89,820,446–89,822,391 | 188.0 kb | Distal (>10kb) Multiome | 889 | |
| chr1:89,842,655–89,844,211 | 210.6 kb | Distal (>10kb) Multiome | 610 | |
| chr1:89,910,443–89,911,186 | 278.0 kb | Distal (>10kb) Multiome | 247 |
Genomic view of the LRRC8C-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.