Predicted to enable signaling receptor binding activity. Predicted to be involved in regulation of synapse assembly and synaptic membrane adhesion. Predicted to be located in cerebellar mossy fiber and presynaptic membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,311,942–50,312,908 | 256.1 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 254.2 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 252.5 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 242.6 kb | Distal (>10kb) Multiome | 748 | |
| chr19:50,328,019–50,330,066 | 239.1 kb | Distal (>10kb) Multiome | 699 | |
| chr19:50,330,341–50,331,411 | 237.5 kb | Distal (>10kb) Multiome | 479 | |
| chr19:50,332,395–50,334,325 | 234.9 kb | Distal (>10kb) Multiome | 907 | |
| chr19:50,368,630–50,369,092 | 199.5 kb | Distal (>10kb) Multiome | 311 | |
| chr19:50,376,225–50,377,452 | 191.5 kb | Distal (>10kb) Multiome | 931 | |
| chr19:50,383,444–50,384,805 | 184.2 kb | Distal (>10kb) Multiome | 863 | |
| chr19:50,414,638–50,415,204 | 153.5 kb | Distal (>10kb) Multiome | 377 | |
| chr19:50,431,430–50,432,503 | 136.6 kb | Distal (>10kb) Multiome | 530 | |
| chr19:50,475,914–50,477,044 | 92.0 kb | Distal (>10kb) Multiome | 622 | |
| chr19:50,510,707–50,511,948 | 57.1 kb | Distal (>10kb) Multiome | 794 | |
| chr19:50,556,266–50,557,084 | 11.6 kb | Distal (>10kb) Multiome | 463 | |
| chr19:50,639,246–50,640,210 | 71.2 kb | Distal (>10kb) Multiome | 326 | |
| chr19:50,657,814–50,659,557 | 90.9 kb | Distal (>10kb) Multiome | 790 | |
| chr19:50,723,765–50,725,772 | 156.5 kb | Distal (>10kb) Multiome | 721 | |
| chr19:50,728,202–50,728,738 | 160.1 kb | Distal (>10kb) Multiome | 345 | |
| chr19:50,804,189–50,805,375 | 236.5 kb | Distal (>10kb) Multiome | 919 | |
| chr19:50,835,543–50,836,598 | 267.6 kb | Distal (>10kb) Multiome | 561 |
Genomic view of the LRRC4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.