LRRC45

leucine rich repeat containing 45 | MGC20806

Located in cytosol; microtubule organizing center; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 8 terms

centriole (GO:0005814)centrosome (GO:0005813)centrosome (GO:0005813)centrosome (GO:0005813)ciliary basal body (GO:0036064)cilium assembly (GO:0060271)protein binding (GO:0005515)protein localization to centriolar satellite (GO:0120329)

Expression (TPM)

TFs regulating LRRC45 0 TFs

Transcription factors with Perturb-seq knockdown data for LRRC45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LRRC45

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:81,832,473–81,833,976	190.0 kb	Distal (>10kb) Multiome	1015
chr17:81,859,762–81,861,595	162.5 kb	Distal (>10kb) Multiome	1134
chr17:81,868,421–81,868,978	154.7 kb	Distal (>10kb) Multiome	577
chr17:81,869,000–81,872,289	152.1 kb	Distal (>10kb) Multiome	1136
chr17:81,891,143–81,892,257	131.5 kb	Distal (>10kb) Multiome	969
chr17:81,910,443–81,911,980	111.7 kb	Distal (>10kb) Multiome	806
chr17:81,917,586–81,918,522	105.1 kb	Distal (>10kb) Multiome	619
chr17:81,923,285–81,923,863	99.8 kb	Distal (>10kb) Multiome	399
chr17:81,926,141–81,929,133	95.4 kb	Distal (>10kb) Multiome	1034
chr17:81,936,855–81,937,682	86.0 kb	Distal (>10kb) Multiome	854
chr17:81,959,299–81,962,169	63.6 kb	Distal (>10kb) Multiome	805
chr17:81,966,804–81,968,359	55.2 kb	Distal (>10kb) Multiome	908
chr17:81,976,595–81,978,312	45.6 kb	Distal (>10kb) Multiome	1001
chr17:82,019,856–82,020,391	3.2 kb	Proximal (<10kb) Multiome	436
chr17:82,022,355–82,024,111	219 bp	At TSS Multiome	898
chr17:82,029,976–82,032,662	8.6 kb	Proximal (<10kb) Multiome	695
chr17:82,036,902–82,037,961	14.3 kb	Distal (>10kb) Multiome	892
chr17:82,051,387–82,052,184	28.5 kb	Distal (>10kb) Multiome	479
chr17:82,065,558–82,066,150	42.5 kb	Distal (>10kb) Multiome	967
chr17:82,096,478–82,100,203	75.2 kb	Distal (>10kb) Multiome	1085
chr17:82,103,334–82,104,356	80.3 kb	Distal (>10kb) Multiome	672
chr17:82,212,405–82,213,592	189.6 kb	Distal (>10kb) Multiome	911
chr17:82,228,266–82,232,536	205.7 kb	Distal (>10kb) Multiome	1048
chr17:82,272,608–82,274,062	250.4 kb	Distal (>10kb) Multiome	943
chr17:82,278,488–82,279,226	255.6 kb	Distal (>10kb) Multiome	229
chr17:82,292,400–82,293,256	269.6 kb	Distal (>10kb) Multiome	944

Genome Browser

Genomic view of the LRRC45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.