Predicted to be involved in cell differentiation. Predicted to act upstream of or within gene expression and telomere maintenance. Predicted to be located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:169,658,211–169,659,014 | 153.9 kb | Distal (>10kb) Multiome | 212 | |
| chr3:169,661,423–169,664,653 | 149.1 kb | Distal (>10kb) Multiome | 840 | |
| chr3:169,668,169–169,669,789 | 143.5 kb | Distal (>10kb) Multiome | 655 | |
| chr3:169,764,381–169,765,564 | 47.6 kb | Distal (>10kb) Multiome | 782 | |
| chr3:169,769,273–169,770,082 | 43.1 kb | Distal (>10kb) Multiome | 566 | |
| chr3:169,771,800–169,773,839 | 40.7 kb | Distal (>10kb) Multiome | 1077 | |
| chr3:169,811,873–169,814,235 | 59 bp | At TSS Multiome | 581 | |
| chr3:169,820,542–169,820,883 | 8.0 kb | Proximal (<10kb) | 35 | |
| chr3:169,966,015–169,967,550 | 154.1 kb | Distal (>10kb) Multiome | 1017 | |
| chr3:170,037,354–170,039,248 | 225.3 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the LRRC34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.