Transcription factors with Perturb-seq knockdown data for LRRC27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:132,035,668–132,037,081 | 295.5 kb | Distal (>10kb) Multiome | 214 | |
| chr10:132,112,772–132,114,093 | 218.8 kb | Distal (>10kb) Multiome | 141 | |
| chr10:132,185,497–132,188,136 | 146.5 kb | Distal (>10kb) Multiome | 418 | |
| chr10:132,306,849–132,308,922 | 24.1 kb | Distal (>10kb) Multiome | 613 | |
| chr10:132,331,380–132,332,787 | 86 bp | At TSS Multiome | 823 | |
| chr10:132,395,781–132,397,421 | 64.0 kb | Distal (>10kb) Multiome | 555 | |
| chr10:132,453,126–132,453,618 | 121.1 kb | Distal (>10kb) Multiome | 512 | |
| chr10:132,536,764–132,538,979 | 205.4 kb | Distal (>10kb) Multiome | 715 | |
| chr10:132,571,796–132,572,566 | 240.0 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the LRRC27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.